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We obtained data from the British Columbia PharmaNet database

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on all outpatient oral antimicrobial prescriptions from aciclovir tablets 800mg 1996 to 2000 and

antibiotics

converted them to their defined daily

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dose (DDD) equivalents according to the ATC system. After the listing of valAcyclovir

antibiotics

indinavir

/ Aciclovir on the formulary, the rate of change in its monthly consumption

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increased 57% from a baseline

avelox

of 0.0014 to 0.0022 DDD/1000 population/day (P 0.07). Formularies are used routinely for management

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of drug expenditures yet evaluations of their

tetracycline

impact remain rare. Maximum likelihood estimation was used to determine the rate

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of increase

azithromycin

in utilization resulting from addition to the formulary. ValAcyclovir / Aciclovir and Famciclovir ( Famvir ) were also added

aldara

to the formulary. Effect of formulary policy decisions on antimicrobial

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drug utilization in British Columbia.Background.

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Models were adjusted for seasonal and temporal trends as well as serial correlation. During this time period, clarithromycin was on formulary, later delisted, and then relisted again. The objective of this

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study was to analyse the impact of addition or deletion of antimicrobials from the provincial formulary on drug utilization. A similar effect was seen with the addition of Famciclovir ( Famvir ) to the formulary whereby the rate of change in monthly consumption increased from 0.0008 (before addition to the formulary) to 0.0018 (after addition to the

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formulary) (P. During the time clarithromycin was off the formulary, the rate of change in its monthly consumption was 0.0061 DDD/1000 population/day; following its relisting, the rate of change increased by 818% to 0.0560 DDD/1000 population/day (P 0.002). Trends in utilization associated with a changing formulary status of new antimicrobial agents were analysed.